AMPBench-MT: A Homology-Controlled Benchmark for Antimicrobial Peptide Potency, Spectrum, and Safety Prediction

Researchers introduced AMPBench-MT, a provenance-preserving benchmark for antimicrobial peptide modeling.

It evaluates binary AMP recognition, species-conditioned potency, and safety-related endpoints such as hemolysis and toxicity.

Results show that strong AMP/non-AMP classification does not necessarily improve assay-level prediction performance.

Different model families behave differently across endpoints, underscoring the need for more realistic evaluation.