Why Hasn’t a Cure for Alzheimer’s Disease Been Found Even After More Than 100 Years of Research?

Despite more than a century of study and about $4 billion a year in U.S. funding, Alzheimer’s still has no proven treatment that can stop or reverse its progression.

The long-dominant amyloid-β hypothesis has shaped research for years, but its limits are increasingly questioned.

Image irregularities and paper retractions have also raised concerns about research reliability in the field.

The debate is prompting calls to rethink both drug-development strategy and the broader research system.