New microscopy method speeds up 3D brain scans using fewer measurements

University of Hong Kong researchers developed AIMED, a compressed microscopy method for faster 3D brain imaging with fewer measurements.

The system uses optical encoding and computational reconstruction to produce multiphoton images with lower laser power and comparable quality.

Tests on mouse brain tissue showed it could clearly resolve fine structures such as dendritic spines.

The approach may speed volumetric imaging while reducing photodamage, making deep-tissue studies and fragile samples easier to image over longer periods.