The mechanism by which heavy drinking damages the intestines, reported by a U.S. team: Is it really okay “if only once in a while”? : A bit old Innovative Tech

A U.S. research team showed in mice that short-term binge drinking can trigger inflammation and injury in the proximal small intestine.

After binge drinking, neutrophils accumulated in the gut and overproduced NETs, leading to villus damage and endotoxin leakage.

The antioxidant NAC did not prevent the damage, but DNase reduced injury by breaking down NETs.