People Who Stop Ozempic Often Don’t Gain the Weight Back

A Cleveland Clinic study of nearly 8,000 adults found many patients kept most of their weight loss one year after stopping semaglutide or tirzepatide.

Unlike earlier trials, real-world patients often restarted treatment, switched medications, or used lifestyle changes to limit weight regain.

The results suggest stopping GLP-1 drugs does not always cause major rebound weight gain, especially when ongoing support is available.