Why Weight Loss Isn’t Enough for Everyone at Risk of Diabetes

German researchers found that one high-risk diabetes subgroup, cluster 5, kept worsening blood sugar control despite sustained weight loss and healthier habits.

The study suggests their risk is driven by biology, especially insulin resistance linked to fatty liver disease and impaired insulin secretion.

This means standard lifestyle advice may not be enough for everyone at risk of type 2 diabetes.

The findings support more personalized prevention and treatment strategies based on diabetes risk clusters.