Unexpected Drug Combo May Supercharge Weight Loss in Older Women

A retrospective study of 120 women found those using tirzepatide plus menopausal hormone therapy lost more weight than those on tirzepatide alone.

After about 15 months, the combination group lost 19.2% of starting body weight versus 14.0% for tirzepatide alone, a 5.2 percentage‑point difference.

Researchers plan randomized controlled trials to test whether hormone therapy enhances GLP-1 drug effects and to examine cardiometabolic outcomes.