New Research Uncovers Hidden Side Effects of Popular Weight-Loss Drugs

University of Pennsylvania researchers used AI to analyze more than 400,000 Reddit posts about GLP-1 weight-loss drugs.

Along with expected side effects like nausea, the study flagged potentially underreported issues such as menstrual irregularities, chills, and hot flashes.

The findings suggest patient-generated online data can reveal safety signals that may be missed or delayed in trials and formal reporting.

The work could help guide follow-up drug safety research on semaglutide, tirzepatide, and related medications.