Researchers Discover the Body’s Hidden “Off Switch” for Inflammation

UCL researchers identified a natural fat-molecule pathway that helps switch off inflammation.

Epoxy-oxylipins, regulated by soluble epoxide hydrolase, were shown to limit inflammatory immune-cell buildup in humans.

Blocking sEH with GSK2256294 boosted these molecules, sped pain resolution, and reduced intermediate monocytes in an induced inflammation test.

The discovery suggests a more selective way to calm harmful inflammation without broadly suppressing immunity.