Scientists Restore Memory in Aging Mice Using a Simple Nasal Spray

Texas A&M researchers used a two-dose intranasal spray of stem-cell-derived extracellular vesicles in 18-month-old mice and found less hippocampal inflammation and better memory performance.

The treatment appears to work through microRNAs inside the vesicles, which help dampen neuroinflammatory signals and improve microglial function.

The findings point to a less invasive strategy for targeting age-related brain inflammation linked to memory loss and dementia.

The team says human studies are still needed to determine whether the approach can help with cognitive decline in people.