Scientists Discover a Key Difference in Brains That Resist Alzheimer's

UC San Diego researchers identified chromogranin A as a possible molecular link between Alzheimer’s brain pathology and memory loss.

In postmortem human brains and mouse models, they found an Alzheimer’s-related gene signature and a factor that may help explain cognitive resilience.

Mice without chromogranin A still developed amyloid and tau changes, but did not show the memory loss seen in normal mice.

The protective effect appeared stronger in females, suggesting sex differences may matter in resistance to Alzheimer’s symptoms.

The findings could help guide biomarkers and therapies aimed at preventing cognitive decline, even when plaques and tangles are present.