Why has there been so little progress on Alzheimer's disease? | Hacker News

A Hacker News discussion says Alzheimer’s research stalled after the field became overly committed to the amyloid-beta hypothesis.

Commenters argue that weak evidence, selective funding, and gatekeeping kept attention on a model that may have been wrong.

Some also raise allegations of scientific misconduct, including possible data manipulation, as a factor that distorted the field.

The debate underscores how flawed assumptions and institutional incentives can slow progress on a major unmet medical need.