Scientists Discover Surprising Anti-Aging Power Hidden in Aged Garlic

Japanese researchers identified S-1-propenyl-L-cysteine, a compound in aged garlic extract, as a key activator of a newly described fat-to-brain-to-muscle signaling pathway.

In cell, mouse, and human studies, the compound boosted eNAMPT-related signaling and was linked to improved muscle strength in aged mice.

The pathway appears to involve adipose tissue, the hypothalamus, and skeletal muscle, with downstream effects on NAD+ and aging-related muscle function.

If confirmed in larger trials, aged garlic extract could offer a practical nutraceutical approach to help preserve muscle and reduce frailty with age.